Silacyclic Derivatives of Heteroaromatic Sulfides as Selective Cholesterol Level Lowering and Vasodilating Agents
نویسندگان
چکیده
Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K(2)CO(3) / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl and 1,3,4-triazolyl thiols selectively lowered the low density lipoprotein (LDL) level in mice with the high cholesterol diet in nutrition.
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ورودعنوان ژورنال:
- Metal-Based Drugs
دوره 8 شماره
صفحات -
تاریخ انتشار 2002